FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

GRAS Flavoring Substances 21

tion. During a GRAS assessment of a substance, the Expert Panel evaluates a combination of relevant data, including data specific to the substance as well as data for the chemical group to which the substance belongs. For example, a pyrazine derivative is reviewed individually and in the context of its chemical group (42 other pyrazine derivatives) (Smith et al., 2002a). The analysis of food an...

The 20th publication by the Expert Panel of the Flavor and Extract Manufacturers Association on recent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment

n 1958, Congress enacted the Food Additives Amendment (FAA) to the Federal Food, Drug, and Cosmetics Act amid growing concern over the safety of substances added to foods. The FAA set forth standards and guidelines by which the safety of food additives must be established before they can be added to foods (FAA, 1958). The FAA contained an exclusion provided by Congress for substances “generally...

Chemoinformatic Analysis of GRAS (Generally Recognized as Safe) Flavor Chemicals and Natural Products

Food materials designated as "Generally Recognized as Safe" (GRAS) are attracting the attention of researchers in their attempts to systematically identify compounds with putative health-related benefits. In particular, there is currently a great deal of interest in exploring possible secondary benefits of flavor ingredients, such as those relating to health and wellness. One step in this direc...

GRAS Final Layout

Amendment s the FEMA Expert Panel enters its fifth decade, it continues to conduct a comprehensive program of safety evaluation of flavoring substances under the authority of Section 201(s) of the Federal Food, Drug, and Cosmetic Act, a provision commonly known as the GRAS (“generally recognized as safe”) provision. Expert Panel activities primarily involve the evaluation of new flavoring subst...

GRAS: time-tested, and trusted, food ingredients.